Article

Investigation of Prevention, Protection and Treatment of Lopinavir Effectiveness on Coronavirus Disease–2019 (COVID–19) Infection Using Fourier Transform Raman (FT–Raman) Biospectroscopy
Dr. Alireza Heidari* ,

Details

Author

Dr. Alireza Heidari*

ISSN

2737-4033

DOI

doi.org/10.5281/zenodo.3901103

Published on

Jun 19, 2020

Abstract

Lopinavir is an antiretroviral of the protease inhibitor class. It is used against HIV infections as a fixed–dose combination with another protease inhibitor, ritonavir (lopinavir/ritonavir). In the current research, the stimulated FT–Raman biospectroscopy of liquid sample of Lopinavir was investigated. The stimulated FT–Raman diffractions emitted through focusing the second harmonic laser beam Nd:YAG into the sample were recorded by Echelle spectrometer and ICCD detector. Increasing the energy of laser beam from 2.6 (mJ) to 16 (mJ) was led to increase in stimulated FT–Raman signal but after breakdown threshold of liquid sample, more increasing of energy was led to decrease in stimulate FT–Raman signals and for energies higher than 20 (mJ), they were disappeared.

Keywords

FT–Raman Biospectroscopy, Stimulated FT–Raman Biospectroscopy, Lopinavir, Breakdown, Coronavirus Disease–2019, COVID–19, Infection, Protective and Therapeutic Effect, Potent Drug

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